Recent publications highlight groundbreaking findings on the genetic mechanisms of heart disease, novel therapeutic approaches for heart failure, and innovative strategies for improving cardiovascular health outcomes.
Doxorubicin exposure leads to cardiac fibroblast dysregulation and worsens fibrotic remodeling in the pathological heart.
Bagchi S, Cai A, Bilal AS, Gamez-Luque J, Rosa-Garrido M, Patton B, Kala M, Glembotski CC, Blackwood EA.
J Mol Cell Cardiol Plus. 2026. doi: 10.1016/j.jmccpl.2026.100846. PMID: 42022755.
A review of peroxisome biology: Potential implications for cardiac physiology and pathology
Rungreang PJ, Noudali S, Blackwood EA, Tham YK.
J Mol Cell Cardiol. 2026. doi: 10.1016/j.yjmcc.2026.03.003. PMID: 41861913.
Modeling heart failure with preserved ejection fraction in female mice: an elusive target.
Hale TM, Blackwood EA.
Am J Physiol Heart Circ Physiol. 2024. doi: 10.1152/ajpheart.00139.2024. PMID: 38668704.
ATF6 protects against protein misfolding during cardiac hypertrophy.
Hofmann C, Aghajani M, Alcock CD, Blackwood EA, Sandmann C, Herzog N, Groß J, Plate L, Wiseman RL, Kaufman RJ, Katus HA, Jakobi T, Völkers M, Glembotski CC, Doroudgar S.
J Mol Cell Cardiol. 2024. doi: 10.1016/j.yjmcc.2024.02.001. PMID: 38401179.
ER-Specific Autophagy or ER-Phagy in Cardiac Myocytes Protects the Heart Against Doxorubicin-Induced Cardiotoxicity.
Glembotski CC, Bagchi S, Blackwood EA.
JACC CardioOncol. 2023. doi: 10.1016/j.jaccao.2023.08.004. PMID: 37969647.
Optimization of Large-Scale Adeno-Associated Virus (AAV) Production.
Bilal AS, Parker SN, Murray VB, MacDonnell LF, Thuerauf DJ, Glembotski CC, Blackwood EA.
Curr Protoc. 2023. doi: 10.1002/cpz1.757. PMID: 37166238.
Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer’s disease hallmarks.
Dave N, Judd JM, Decker A, Winslow W, Sarette P, Villarreal Espinosa O, Tallino S, Bartholomew SK, Bilal A, Sandler J, McDonough I, Winstone JK, Blackwood EA, Glembotski C, Karr T, Velazquez R.
Aging Cell. 2023. doi: 10.1111/acel.13775. PMID: 36642814.
Noncanonical Form of ERAD Regulates Cardiac Hypertrophy.
Blackwood EA, MacDonnell LF, Thuerauf DJ, Bilal AS, Murray VB, Bedi KC Jr, Margulies KB, Glembotski CC.
Circulation. 2023. doi: 10.1161/CIRCULATIONAHA.122.061557. PMID: 36317534.
Hydrogen sulfide: the gas that fuels longevity.
Blackwood EA, Glembotski CC.
J Cardiovasc Aging. 2022. doi: 10.20517/jca.2022.16. PMID: 36776272.
Design and Production of Heart Chamber-Specific AAV9 Vectors.
Bilal AS, Thuerauf DJ, Blackwood EA, Glembotski CC.
Methods Mol Biol. 2022. doi: 10.1007/978-1-0716-2707-5_8. PMID: 36040589.
Optimization of Large-Scale Adeno-Associated Virus (AAV) Production.
Bilal AS, Parker SN, Murray VB, MacDonnell LF, Thuerauf DJ, Glembotski CC, Blackwood EA.
Curr Protoc. 2023. doi: 10.1002/cpz1.757. PMID: 37166238.
Optimizing Adeno-Associated Virus Serotype 9 for Studies of Cardiac Chamber-Specific Gene Regulation.
Bilal AS, Blackwood EA, Thuerauf DJ, Glembotski CC.
Circulation. 2021. doi: 10.1161/CIRCULATIONAHA.120.052437. PMID: 33999662.
The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes.
Marsh KG, Arrieta A, Thuerauf DJ, Blackwood EA, MacDonnell L, Glembotski CC.
Am J Physiol Heart Circ Physiol. 2021. doi: 10.1152/ajpheart.00999.2020. PMID: 33666503.
Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart.
Blackwood EA, Bilal AS, Azizi K, Sarakki A, Glembotski CC.
J Vis Exp. 2020. doi: 10.3791/61224. PMID: 32597844.
Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response.
Blackwood EA, Thuerauf DJ, Stastna M, Stephens H, Sand Z, Pentoney A, Azizi K, Jakobi T, Van Eyk JE, Katus HA, Glembotski CC, Doroudgar S.
J Mol Cell Cardiol. 2020. doi: 10.1016/j.yjmcc.2020.04.012. PMID: 32339566.
Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart.
Arrieta A, Blackwood EA, Stauffer WT, Santo Domingo M, Bilal AS, Thuerauf DJ, Pentoney AN, Aivati C, Sarakki AV, Doroudgar S, Glembotski CC.
J Biol Chem. 2020. doi: 10.1074/jbc.RA120.013345. PMID: 32327487.
ATF6 as a Nodal Regulator of Proteostasis in the Heart.
Glembotski CC, Arrieta A, Blackwood EA, Stauffer WT.
Front Physiol. 2020. doi: 10.3389/fphys.2020.00267. PMID: 32322217.
Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis.
Blackwood EA, Bilal AS, Stauffer WT, Arrieta A, Glembotski CC.
Cells. 2020. doi: 10.3390/cells9030602. PMID: 32138230.
The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts.
Stauffer WT, Blackwood EA, Azizi K, Kaufman RJ, Glembotski CC.
Int J Mol Sci. 2020. doi: 10.3390/ijms21041373. PMID: 32085622.
Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α.
Stauffer WT, Arrieta A, Blackwood EA, Glembotski CC.
Cells. 2020. doi: 10.3390/cells9030602. PMID: 32138230.
Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart.
Arrieta A, Blackwood EA, Stauffer WT, Glembotski CC.
Front Cardiovasc Med. 2020. doi: 10.3389/fcvm.2019.00193. PMID: 32010709.
Reactive Oxygen Species (ROS)-Activatable Prodrug for Selective Activation of ATF6 after Ischemia/Reperfusion Injury.
Palmer JE, Brietske BM, Bate TC, Blackwood EA, Garg M, Glembotski CC, Cooley CB.
ACS Med Chem Lett. 2019. doi: 10.1021/acsmedchemlett.9b00299. PMID: 32184959.
Unfolding the Roles of Mitochondria as Therapeutic Targets for Heart Disease.
Glembotski CC, Arrieta A, Blackwood EA.
J Am Coll Cardiol. 2019. doi: 10.1016/j.jacc.2018.12.089. PMID: 30975298.
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.
Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC.
Nat Commun. 2019. doi: 10.1038/s41467-018-08129-2. PMID: 30643122.
ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb.
Blackwood EA, Hofmann C, Santo Domingo M, Bilal AS, Sarakki A, Stauffer W, Arrieta A, Thuerauf DJ, Kolkhorst FW, Müller OJ, Jakobi T, Dieterich C, Katus HA, Doroudgar S, Glembotski CC.
Circ Res. 2019. doi: 10.1161/CIRCRESAHA.118.313854. PMID: 30582446.
Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins.
Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW.
Elife. 2018. doi: 10.7554/eLife.37168. PMID: 30084354.
ER Protein Quality Control and the Unfolded Protein Response in the Heart.
Arrieta A, Blackwood EA, Glembotski CC.
Curr Top Microbiol Immunol. 2018. doi: 10.1007/82_2017_54. PMID: 29026925.
CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α.
Gray CB, Suetomi T, Xiang S, Mishra S, Blackwood EA, Glembotski CC, Miyamoto S, Westenbrink BD, Brown JH.
J Mol Cell Cardiol. 2017. doi: 10.1016/j.yjmcc.2017.01.002. PMID: 28077321.
ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart.
Jin JK, Blackwood EA, Azizi K, Thuerauf DJ, Fahem AG, Hofmann C, Kaufman RJ, Doroudgar S, Glembotski CC.
Circ Res. 2017. doi: 10.1161/CIRCRESAHA.116.310266. PMID: 27932512