Recent publications highlight groundbreaking findings on the genetic mechanisms of heart disease, novel therapeutic approaches for heart failure, and innovative strategies for improving cardiovascular health outcomes.
Enhancing mitochondrial pyruvate metabolism ameliorates myocardial ischemic reperfusion injury.
Visker JR, Cluntun AC, Ling J, Kwak H, Shankar T, Hamouche R, Navankasattusas S, Ducker G, Rutter JP, Drakos SG.
JCI Insight. 2024. doi: 10.1172.180906. PMID: 38352459.
Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support.
Drakos SG, Badolia R, Makaju A, Kyriakopoulos CP, Wever-Pinzon O, Tracy CM, Bakhtina A, Bia R, Parnell T, Taleb I, Ramadurai DKA, Navankasattusas S, Dranow E, Hanff TC, Tseliou E, Shankar TS, Visker J, Hamouche R, Stauder EL, Caine WT, Alharethi R, Selzman CH, Franklin S.
Circulation. 2023 Jan 31; 147(5):409-424.
Defining cardiac functional recovery in end-stage heart failure at single-cell resolution
Junedh M. Amrute, Lulu Lai, Pan Ma, Andrew L. Koenig, Kenji Kamimoto, Andrea Bredemeyer, Thirupura S. Shankar, Christoph Kuppe, Farid F. Kadyrov, Linda J. Schulte, Dylan Stoutenburg, Benjamin J. Kopecky, Sutip Navankasattusas, Joseph Visker, Samantha A. Morris, Rafael Kramann, Florian Leuschner, Douglas L. Mann, Stavros G. Drakos & Kory J. Lavine
Nature Cardiovascular Research, In Press
Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis.
Shankar TS, Ramadurai DKA, Steinhorst K, Sommakia S, Badolia R, Krokidi AT, Calder D, Sander P, Kwon OS, Ling J, Dendorfer A, Xie C, Kwon O, Cheng EHY, Whitehead KJ, Richardson RS, Sachse FB, Schredelseker J, Spitzer KW, Chaudhuri D, Drakos SG.
Nature Communications, In Press
The Pyruvate-Lactate Axis Modulates Cardiac Hypertrophy and Heart Failure.
Cluntun AC, Badolia R, Lettlova S, Parnell KM, Shankar T, Diakos NA, Olson KA, Taleb I, Tatum SM, Berg JA, Cunningham CN, Van Ry T, Bott AJ, Thodou A, Fogarty S, Skedros S, Swiatek WI, Yu X, Luo B, Merx S, Navankasattusas S, Cox JE, Ducker GS, Holland WL, McKellar SH, Rutter J, Drakos SG.
Cell Metabolism, In Press
Use of a Pulmonary Artery Pressure Sensor to Manage Patients With Left Ventricular Assist Devices.
Thohan V, Abraham J, Burdorf A, Sulemanjee N, Jaski B, Guglin M, Pagani FD, Vidula H, Majure DT, Napier R, Heywood TJ, Cogswell R, Dirckx N, Farrar DJ, Drakos SG;
INTELLECT 2-HF Investigators. Circ Heart Fail. 2023 Apr 20.
The Role of Non-Glycolytic Glucose Metabolism in Myocardial Recovery upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure.
Badolia R, Ramadurai DKA, Abel ED, Ferrin P, Taleb I, Shankar TS, Thodou Krokidi A, Navankasattusas S, McKellar SH, Yin M, Kfoury AG, Wever-Pinzon O, Fang JC, Selzman CH, Chaudhuri D, Rutter J, Drakos SG.
Circulation. 2020 Apr 30. doi: 10.1161/CIRCULATIONAHA.119.044452. Online ahead of print. PMID: 32351122
Prospective Multicenter Study of Myocardial Recovery Using Left Ventricular Assist Devices (RESTAGE-HF [Remission from Stage D Heart Failure]): Medium-Term and Primary End Point Results.
Birks EJ*, Drakos SG* (co-corresponding authors), Patel SR, Lowes BD, Selzman CH, Starling RC, Trivedi J, Slaughter MS, Alturi P, Goldstein D, Maybaum S, Um JY, Margulies KB, Stehlik J, Cunningham C, Farrar DJ, Rame JE.
Circulation. 2020 Nov 24; 142(21):2016-2028.
P Circulating and Myocardial Cytokines Predict Cardiac Structural and Functional Improvement in Patients With Heart Failure Undergoing Mechanical Circulatory Support.
Diakos NA, Taleb I, Kyriakopoulos CP, Shah KS, Javan H, Richins TJ, Yin MY, Yen CG, Dranow E, Bonios MJ, Alharethi R, Koliopoulou AG, Taleb M, Fang JC, Selzman CH, Stellos K, Drakos SG.
J Am Heart Assoc. 2021 Oct 19; 10(20):e020238.
Biology of myocardial recovery in advanced heart failure with long-term mechanical support.
Tseliou E, Lavine KJ, Wever-Pinzon O, Topkara VK, Meyns B, Adachi I, Zimpfer D, Birks EJ, Burkhoff D, Drakos SG.
J Heart Lung Transplant. 2022 Oct; 41(10):1309-1323.
A Mechanical Bridge to Recovery as a Bridge to Discovery: Learning From Few and Applying to Many.
Taleb I, Tseliou E, Fang JC, Drakos SG.
Circulation. 2022 Feb 22; 145(8):562-564.
Framework to Classify Reverse Cardiac Remodeling With Mechanical Circulatory Support: The Utah-Inova Stages.
Shah P, Psotka M, Taleb I, Alharethi R, Shams MA, Wever-Pinzon O, Yin M, Latta F, Stehlik J, Fang JC, Diao G, Singh R, Ijaz N, Kyriakopoulos CP, Zhu W, May CW, Cooper LB, Desai SS, Selzman CH, Kfoury AG, Drakos SG.
Circ Heart Fail. 2021 May; 14(5):e007991
Heart Failure Strategically Focused Research Network: Summary of Results and Future Directions.
Felker GM, Buttrick P, Rosenzweig A, Abel ED, Allen LA, Bristow M, Das S, DeVore AD, Drakos SG, Fang JC, Freedman JE, Hernandez AF, Li DY, McKinsey TA, Newton-Cheh C, Rogers JG, Shah RV, Shah SH, Stehlik J, Selzman CH.
J Am Heart Assoc. 2022 Sep 20; 11(18):e025517.
Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes.
Maron BA, Wang RS, Shevtsov S, Drakos SG, Arons E, Wever-Pinzon O, Huggins GS, Samokhin AO, Oldham WM, Aguib Y, Yacoub MH, Rowin EJ, Maron BJ, Maron MS, Loscalzo J.
Nat Commun. 2021 Feb 8; 12(1):873.
Learn MoreShort Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart.
Carley AN, Maurya SK, Fasano M, Wang Y, Selzman CH, Drakos SG, Lewandowski ED.
Circulation. 2021 Feb 19.
Cardiomyocyte Krüppel-like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy.
Hoffman M, Palioura D, Kyriazis ID, Cimini M, Badolia R, Rajan S, Gao E, Nikolaidis N, Schulze PC, Goldberg IJ, Kishore R, Bialkowska AB, Selzman CH, Drakos SG, Drosatos K.
Circulation. 2021 Jan 12.
Effect of Continuous-Flow Left Ventricular Assist Device Support on Coronary Artery Endothelial Function in Ischemic and Nonischemic Cardiomyopathy.
Symons JD, Deeter L, Bonn T, Ferrin P, McCreath L, Diakos NA, Taleb I, Alharethi R, McKellar S, Wever-Pinzon O, Navankasattusas S, Selzman CH, Fang JC, Drakos SG.
Circ Heart Fail. 2019 Aug;12(8):e006085. doi: 10.1161/CIRCHEARTFAILURE.119.006085. Epub 2019 Aug 19. PMID: 31422672
Learn MorePercutaneous Mechanical Unloading Simultaneously With Reperfusion Induces Increased Myocardial Salvage in Experimental Acute Myocardial Infarction
Ko B, Drakos SG*, Ibrahim H, Kang TS, Thodou A, Bonios M, Taleb I, Welt FG* (*co-corresponding authors).
Circ Heart Fail. 2020 Jan; 13(1):e005893. doi: 10.1161/CIRCHEARTFAILURE.119.005893. Epub 2020 Jan 21. PMID: 31959013
Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling.
Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Abel ED.
JCI Insight. 2020 Mar 26; 5(6):134920. doi: 10.1172/jci.insight.134920. PMID: 32213702
DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure.
Pepin ME, Drakos SG, Ha CM, Tristani-Firouzi M, Selzman CH, Fang JC, Wende AR, Wever-Pinzon O.
Circ Heart Fail. 2019 Oct; 12(10):e006191. doi: 10.1161/CIRCHEARTFAILURE.119.006191. Epub 2019 Oct 15. PMID: 31610725
Longitudinal assessment of the platelet transcriptome in advanced heart failure patients following mechanical unloading.
Frey C, Koliopoulou AG, Montenont E, Tolley ND, Javan H, McKellar SH, Drakos SG, Selzman CH, Rondina MT.
Frey C, Koliopoulou AG, Montenont E, Tolley ND, Javan H, McKellar SH, Drakos SG, Selzman CH, Rondina MT. Longitudinal assessment of the platelet transcriptome in advanced heart failure patients following mechanical unloading. Platelets. 2020 Jan 14:1-8. doi: 10.1080/09537104.2020.1714573. [Epub ahead of print] PMID: 31934818
Shock Team Approach in Refractory Cardiogenic Shock Requiring Short-Term Mechanical Circulatory Support: A Proof of Concept.
Taleb I, Koliopoulou AG, Tandar A, McKellar SH, Tonna JE, Nativi-Nicolau J, Alvarez Villela M, Welt F, Stehlik J, Gilbert EM, Wever-Pinzon O, Morshedzadeh JH, Dranow E, Selzman CH, Fang JC, Drakos SG.
Circulation. 2019 Jul 2;140(1):98-100. doi: 10.1161/CIRCULATIONAHA.119.040654.
Targeting Peripheral Vascular Pulsatility in Heart Failure Patients with Continuous-Flow Left Ventricular Assist Devices: The Impact of Pump Speed.
Hydren JR, Kithas AC, Park SH, Wever-Pinzon O, Selzman CH, Perry W, Vargas CAS, Stehlik J, Drakos SG, Richardson RS.
ASAIO J. 2019 Apr 4. doi: 10.1097/MAT.0000000000001001. [Epub ahead of print] PMID: 30973399
Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failure.
Pepin ME, Ha CM, Crossman DK, Litovsky SH, Varambally S, Barchue JP, Pamboukian SV, Diakos NA, Drakos SG, Pogwizd SM, Wende AR.
Lab Invest. 2019 Mar;99(3):371-386. doi: 10.1038/s41374-018-0104-x. Epub 2018 Aug 8. PMID: 30089854
The human heart contains distinct macrophage subsets with divergent origins and functions.
Bajpai G, Schneider C, Wong N, Bredemeyer A, Hulsmans M, Nahrendorf M, Epelman S, Kreisel D, Liu Y, Itoh A, Shankar TS, Selzman CH, Drakos SG, Lavine KJ.
Nat Med. 2018 Jun 11. doi: 10.1038/s41591-018-0059-x.
Cardiac Rotational Mechanics As a Predictor of Myocardial Recovery in Heart Failure Patients Undergoing Chronic Mechanical Circulatory Support: A Pilot Study.
Bonios MJ, Koliopoulou A, Wever-Pinzon O, Taleb I, Stehlik J, Xu W, Wever-Pinzon J, Catino A, Kfoury AG, Horne BD, Nativi-Nicolau J, Adamopoulos SN, Fang JC, Selzman CH, Bax JJ, Drakos SG.
Circ Cardiovasc Imaging. 2018 Apr; 11(4):e007117. doi: 10.1161/CIRCIMAGING.117.007117.
Regional myocardial structural characteristics in ischemic and non-ischemic cardiomyopathy: Left ventricle versus right and apex versus base.
Diakos NA, Passi S, Taleb I, Kfoury AG, Drakos SG.
J Heart Lung Transplant. 2018 Jan; 37(1):166-169
Clinical and histopathological effects of heart failure drug therapy in advanced heart failure patients on chronic mechanical circulatory support.
Catino AB, Ferrin P, Wever-Pinzon J, Horne BD, Wever-Pinzon O, Kfoury AG, McCreath L, Diakos NA, McKellar S, Koliopoulou A, Bonios MJ, Al-Sarie M, Taleb I, Dranow E, Fang JC, Drakos SG.
Eur J Heart Fail. 2018 Jan; 20(1):164-174.
Comparison of two biventricular infarct patterns with respect to the infarct burden required to induce cardiogenic shock: An experimental study. Hellenic J Cardiol.
Koudoumas D, Terrovitis J, Glentis P, Ntalianis A, Tsolakis E, Zannas AS, Tseliou E, Papalois A, Drakos S, Nanas JN.
2017 Jul – Aug;58(4):306-309. doi: 10.1016/j.hjc.2016.11.035. Epub 2016 Dec 5. No abstract available. PMID:27923684
Advancing the Science of Myocardial Recovery With Mechanical Circulatory Support: A Working Group of the National, Heart, Lung, and Blood Institute. J Card Fail.
Drakos SG, Pagani FD, Lundberg MS, Baldwin JT.
2017 May; 23(5):416-421. doi: 10.1016/j.cardfail.2017.04.005. Epub 2017 Apr 19. (Simultaneous publication in JACC: ASAIO J, Basic Transl Sci, J Card Fail, J Thorac Cardiovasc Surg)
Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading.
Seidel T, Navankasattusas S, Ahmad A, Diakos NA, Xu WD, Tristani-Firouzi M, Bonios MJ, Taleb I, Li DY, Selzman CH, Drakos SG, Sachse FB.
Circulation, 2017 Apr 25. Epub 2017 Jan 10. Editorial
Evidence of glycolysis upregulation and pyruvate mitochondrial oxidation mismatch during mechanical unloading of the failing human heart: implications for cardiac reloading and conditioning.
Diakos NA, Navankasattusas S, Abel ED, Rutter J, McCreath L, Ferrin P, McKellar SH, Richardson R, Deberardinis R, Kfoury AG, Selzman CH, Stehlik J, Fang JC, Li DY, Drakos SG.
JACC Bas Transl Sci, Oct 2016-Epub Editorial
Cardiac Recovery During Long-Term Left Ventricular Assist Device Support.
Wever-Pinzon O, Drakos SG, McKellar SH, Kfoury AG, Horne BD, Li DY, Caine W, Stehlik J, Fang JC, Selzman CH.
J Am Coll Cardiol, 2016 Oct 4;68(14):1540-53 Editorial
Myocardial Structural and Functional Response after Long-Term Mechanical Unloading With Continuous-Flow Left Ventricular Assist Device: Axial- versus Centrifugal-Flow.
Al-Sarie M, Rauf A, Kfoury A, Catino A, Wever-Pinzon J, Bonios M, Alharethi R, Reid BB, Wever-Pinzon O, McKellar SH, Fang JC, Stehlik J, Selzman CH, Drakos SG.
JACC Heart Fail. 2016 Jul;4(7):570-6.
Impact of Ischemic Heart Failure Etiology on the Incidence of Cardiac Recovery During Mechanical Unloading: A Prospective Study from the Utah Cardiac Recovery Program.
Wever-Pinzon J, Selzman CH, Wever-Pinzon O, Catino A, Kfoury AG, Stehlik J, Al- Sarie M, Stoddard G, McKellar S, Bonios MJ, Koliopoulou A, Fang JC, Drakos SG.
J Am Coll Cardiol, 2016 Oct 18; 68(16):1741-1752. Editorial
Comparison of two biventricular infarct patterns with respect to the infarct burden required to induce cardiogenic shock: an experimental study.
Koudoumas D, Terrovitis J, Glentis P, Ntalianis A, Tsolakis E, Zannas AS, Tseliou E, Papalois A, Drakos SG, Nanas JN.
Hellenic J Cardiol. 2016 Dec 3. pii: S1109-9666(16)30245-7
Mitochondrial function in heart failure: The impact of ischemic and non-ischemic etiology.
Park SY, Trinity JD, Gifford JR, Diakos NA, McCreath L, Drakos SG, Richardson RS (2016).
Int J Cardiol. 2016; 220: 711-7.
Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy.
Huang ZP, Ding Y, Chen J, Wu G, Kataoka M, Hu Y, Yang JH, Liu J, Drakos SG, Selzman CH, Remedios CG, Pu WT, Wang DZ.
Cardiovascular Research, 2016 Aug 24. pii: cvw201.
The effect of long-term amiodarone administration on myocardial fibrosis and evolution of left ventricular remodeling in a porcine model of ischemic cardiomyopathy.
Zagorianou A, Marougkas M, Drakos SG, Diakos N, Konstantopoulos P, Perrea DN, Anastasiou-Nana M, Malliaras K.
Springerplus. 2016 Sep 15; 5(1):1568. doi: 10.1186/s40064-016-3249-3. eCollection 2016 Sep 15.
Epigenetic response to environmental stress: Assembly of BRG1-G9a/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts.
Han P, Li W, Yang J, Shang C, Lin CH, Cheng W, Hang CT, Cheng HL, Chen CH, Wong J, Xiong Y, Zhao M, Drakos SG, Ghetti A, Li DY, Bernstein D, Chen HS, Quertermous T, Chang CP.
Biochim Biophys Acta. 2016 Jul; 1863(7 Pt B):1772-81.
In search of a physiological definition of myocardial atrophy.
Diakos N, Stehlik J, Sachse F, Selzman C, Koliopoulou A, McKellar S, Fang J, Li DY, Drakos SG (2015).
J Am Coll Cardiol; 65(19):2156-7.
Further Peripheral Vascular Dysfunction in Heart Failure Patients with a Continuous-flow Left Ventricular Assist Device: The role of pulsatility.
Witman MA, Garten RS, Gifford JR, Jonathan H, Trinity JD, Stehlik J, Selzman CH, Drakos SG, Richardson RS (2015).
JACC Heart Fail, 3(9): 703-11. Editorial
Mixed cellular and antibody-mediated rejection in heart transplantation: In-depth pathologic and clinical observations.
Kfoury AG, Miller DV, Snow GL, Afshar K, Stehlik J, Drakos SG, Budge D, Fang JC, Revelo MP, Alharethi RA, Gilbert EM, Caine WT, McKellar S, Molina KM, Hammond ME (2015).
J Heart Lung Transplant. pii: S1053-2498(15)01477-1.
Autophagy is a key feature in the pathogenesis of systemic sclerosis.
Frech T, De Domenico I, Murtaugh MA, Revelo MP, Li DY, Sawitzke AD, Drakos SG (2014).
Rheumatol Int, 34(3), 435-439.
Characterization of Diffuse Fibrosis in the Failing Human Heart via Diffusion Tensor Imaging and Quantitative Histological Validation.
Abdullah OM, Drakos SG, Diakos NA, Stehlik J, Kfoury AG, Selzman CH, Reid BB, Wever-Pinzon O, Kfoury AG, Reid BB, Brunisholz K, Verma DR, Myrick C, Sachse FB, Li DY, Hsu EW (2014).
NMR Biomed. 27(11):1378-86.
Baseline red blood cell osmotic fragility does not predict the degree of post-LVAD hemolysis.
Madden JL, Drakos SG, Stehlik J, McKellar SH, Rondina MT, Weyrich AS, Selzman CH (2014).
ASAIO J, 60(5): 524-8.
Cardiac, skeletal, and smooth muscle mitochondrial function; Are all mitochondria created equal?
Park SY, Gifford JR, Andtbacka R, Hyngstrom JR, Garten RS, Diakos NA, Ives SJ, Dela F, Larson S, Drakos SG, Richardson RS (2014).
Am J Physiol Endocrinol Metab. 307(3):H346-52
Myocardial atrophy and metabolic changes during mechanical unloading of the failing human heart: implications for ventricular assist devices-induced cardiac recovery.
Diakos NA, Selzman CH, Sachse FB, Stehlik J, Kfoury AG, Wever-Pinzon O, Catino A, Alharethi R, Reid BB, Miller DV, Salama ME, Zaitsev AV, Shibayama J, Li H, Fang JC, Li DY, Drakos SG (2014).
J Am Coll Cardiol. 64(15):1602-12 Editorial
Magnitude and time course of changes induced by continuous-flow left ventricular assist device unloading in chronic heart failure: insights into cardiac recovery.
Drakos SG, Wever-Pinzon O, Selzman CH, Gilbert EM, Alharethi R, Reid BB, Saidi A, Diakos NA, Stoker S, Davis ES, Movsesian M, Li DY, Stehlik J, Kfoury AG – Utah Cardiac Recovery Program Investigators (2013).
J Am Coll Cardiol, 61(19), 1985-94. Editorial
Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heart.
Drakos SG, Kfoury AG, Hammond EH, Reid BB, Revelo MP, Rasmusson BY, Whitehead KJ, Salama ME, Selzman CH, Stehlik J, Clayson SE, Bristow MR, Renlund DG, Li DY (2010).
J Am Coll Cardiol, 56(5), 382-91.